The Effect of Trichophytin and Candidin on Neutrophil Chemotaxis/Die Wirkung von Trichophytin und Candidin auf die Neutrophilen-Chemotaxis

Summary:The antigenic extracts of Trichophy- ton and to a lesser extent of Cmdidu were found to inhibit the directed locomotion of polymor- phonuclear leukocytes towards zymosan- activated serum. The inhibitory potential was cell-directed rather than chemotactic factor- directed. The fungal antigens did not affect the neutrophil spontaneous migration. The results may explain, at least in part, the lack of neutrophilic infiltration in certain fungal infections. Zusammenfassung: Antigenextrakte von Tri- chophyton und - in geringerem AusmaD - von Can& hemmen die gerichtete Bewegung polymorphkerniger Leukozyten gegenuber Zymosan-aktiviertem Serum. Das Hemmpo- tential war eher gegen die Zellen als gegen den chemotaktischen Faktor gerichtet. Die Pilzan- tigene beeinflaten nicht die Spontanbeweglich- keit der Neutrophilen. Die Ergebnisse konnten - wenigstens teilweise - das Nichtvorhanden- sein einer Neutrophilen-Infdtration bei gewis- sen Pilzinfektionen erklaren. Leukocyte chemotaxis is defined as the directed migration of polymorphonuclear leukocytes and mononuclear cells toward an infecting organism or its mediators in inflamed areas; thus, it constitutes an essential early step in the mobilization of cells against an infecting agent