脳梗塞患者のVLDL代謝異常:Heparin Affinity Chromatographyによる検討

To elucidate the relationship between the metabolic abnormalities of VLDL and cerebral infarction (CI), we measured lipid concentrations of VLDL and IDL in male survivors of CI and in age-matched healthy males. VLDL was subfractionated by heparin-Sepharose affinity chromatography into heparin unbound fraction (UBF) and heparin bound fraction (BF).We found 1) VLDL concentration was increased in CI patients as compared with controls, although IDL concentration was not increased in CI patients. 2) VLDL-CE/TG ratio and IDL-CE/TG ratio were increased in CI patients. 3) BE was increased in CI patients and BF-CE/TG ratio was higher in CI patients than in controls.We suggest that in CI patients VLDL catabolism by lipoprotein lipase is retarded and that CE is excessively transferred from HDL to VLDL forming the CE-rich lipoprotein particles.