In vitro activities of miltefosine and two novel antifungal biscationic salts against a panel of 77 dermatophytes.

Zhongsheng Tong,Fred Widmer,Tania C Sorrell, Zofia Guse,Katrina A Jolliffe,Catriona Halliday,Ok Cha Lee,Fanrong Kong,Lesley C Wright,Sharon C A Chen

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY（2007）

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摘要

The susceptibilities of 77 dermatophytes to miltefosine (MI), 1,12-bis(4-pentylpyridinium)dodecane (PYR), 1,12-bis(tributylammonium)dodecane (AM), itraconazole (ITC), terbinafine (TRB), and butenafine (BTF) were compared. Geometric mean MICs of TRB, BTF, ITC, MI, PYR, and AM were 0.039, 0.059, 1.718, 0.671, 6.006, and 4.771 mu g/ml, respectively. MI was more active than ITC (P < 0.001).

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