Sex Differences in Insulin Dose and Postprandial Glucose (PPG) as BMI Increases in Patients with Type 2 Diabetes (T2D)

In a recent review by Geer and Shen (1), using the PubMed database and the references cited in these reports, men were reported to have more lean mass and women to have higher adiposity. Men were also found to have more visceral and hepatic adipose tissue, whereas women had more peripheral or subcutaneous adipose tissue. The researchers concluded that these differences, as well as differences in sex hormones and adipokines, may contribute to a more insulin-sensitive environment in women than in men. When they normalized to kilograms of lean body mass, men and women had similar resting energy expenditure, but physical energy expenditure was more closely related to percent body fat in men than in women. Greater amounts of visceral and hepatic adipose tissue, in conjunction with the …