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肝癌病人血浆叶酸和维生素B12水平变化及其意义

FEN-FEN WANG,XIAO-GUANG CHEN,JUAN ZHANG,CHAO-YING ZHANG,YANG SONG,LIAN-HUA CUI

Acta Academiae Medicinae Qingdao Universitatis（2011）

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Abstract
目的 探讨肝癌病人血浆叶酸、维生素B12水平及其与临床特征的关系.方法 采用电化学发光免疫法检测312例肝癌病人和325例健康对照者血浆叶酸和维生素B12水平.结果 肝癌组叶酸水平显著低于对照组(F=77.56,q=8.87,P＜0.05),且肝癌组叶酸缺乏者显著多于对照组(χ2=74.55,P＜0.05);两组维生素B12水平比较差异无显著性(P＞0.05),但肝癌组维生素B12缺乏者明显多于对照组(χ2=5.82,P＜0.05).Ⅰ+Ⅱ期肝癌病人叶酸水平显著高于Ⅲ+Ⅳ期病人(F=4.09,q=2.08,P＜0.05),而维生素B12水平显著低于Ⅲ+Ⅳ期病人(F=5.60,q=2.39,P＜0.05).结论 血浆叶酸和维生素B12水平可能与肝癌进展有一定的关系.
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Key words
folic acid,liver neoplasms,vitamin B12,clinical features
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