Supplementary Tables 1-3, 5-9,Supplementary Figures 1-5 from Infection Exposure Promotes <i>ETV6-RUNX1</i> Precursor B-cell Leukemia via Impaired H3K4 Demethylases

Contents: Supplementary Table 1: Characteristics of the pediatric patients enrolled in whole-genome- and whole-exome-sequencing. Supplementary Table 2: Conventional Facility Health Monitoring Report. Supplementary Table 3: Percentage of hematopoietic subsets in young ETV6-RUNX1 and wild type mice housed in conventional facility. Supplementary Table 5: Differential regulation of histonemodifying genes in ETV6-RUNX1 mice compared to human ETV6-RUNX1 pB-ALL. Supplementary Table 6: Alterations in genes related to histone modification in pB-ALL human samples Supplementary Table 7: Summary of whole genome sequencing statistics. Supplementary Table 8: Summary of exome sequencing statistics. Supplementary Table 9: Validated SNVs in the patient cohort. Supplementary Fig. 1: Distribution of genomic ETV6-RUNX1 breakpoints amongst patients. Supplementary Fig. 2: Development of Sca1-ETV6-RUNX1 mice. Supplementary Fig. 3: pB-ALL development in Sca1-ETV6-RUNX1 mice and B cell development in young Sca1-ETV6-RUNX1 mice housed in SPF facility. Supplementary Fig. 4: Tumor exome sequencing data identify genes mutated in mouse and human. Supplementary Fig. 5: Study of proB cells in young Sca1-ETV6-RUNX1 mice.