Molecular modeling of binding between amidinobenzisothiazoles, with antidegenerative activity on cartilage, and matrix metalloproteinase-3.

Alessio Amadasi,Pietro Cozzini,Matteo Incerti,Elenia Duce,Emilia Fisicaro,Paola Vicini

Bioorganic & Medicinal Chemistry（2007）

引用 12|浏览3

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摘要

N–(Benzo[d]isothiazol-3-yl)-4-chlorobenzamidine bound within the binding site of MMP-3, as predicted by molecular docking calculations using the published 1CIZ X-ray structure.

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关键词

Matrix metalloproteinase-3,Docking,Antiinflammatory,Benzisothiazolylamidines

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