Nuclear factor-kappaB activation in airway epithelium induces inflammation and hyperresponsiveness.

Cristen Pantano,Jennifer L Ather,John F Alcorn,Matthew E Poynter,Amy L Brown,Amy S Guala,Stacie L Beuschel,Gilman B Allen,Laurie A Whittaker,Mieke Bevelander,Charles G Irvin,Yvonne M W Janssen-Heininger

American Journal of Respiratory and Critical Care Medicine（2008）

引用 44|浏览11

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摘要

These findings demonstrate that selective activation NF-kappaB in airway epithelium is sufficient to induce airway hyperresponsiveness and smooth muscle thickening, which are both critical features of allergic airway disease.

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关键词

airway epithelium,nuclear factor-kappa B,inhibitory kappa B kinase-beta,airway hyperresponsiveness,smooth muscle cell

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