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Isoproterenol-induced changes in perfusion, function, energy metabolism and nitric oxide pathway: in vivo and ex vivo study in the rat heart

Martine Desrois,Frank Kober,Carole Lan,Christiane Dalmasso,Mark A Cole,Kieran Clarke,Patrick J Cozzone,Monique Bernard

Journal of Cardiovascular Magnetic Resonance（2011）

Cited 6|Views15
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Abstract
Calcium overload induced by chronic administration of the β-adrenoreceptor agonist, isoproterenol (IP), is used in animal to study the mechanisms of cardiac hypertrophy and failure associated with a sustained increase in circulating catecholamines.
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Key words
Nitric Oxide,Myocardial Perfusion,Cardiac Hypertrophy,Myocardial Blood Flow,Isoproterenol
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