Observation of the Curative Effect of Compound Liver-benepitino in the Prevention of Hepatic Lesion Caused by Antituberculotic

Objective:To assess the clinical efficacy of compound liver-benepitino remedy in preventing liver injury caused by antituberculosis drugs.Methods:We divided 384 tuberculosis patients into treatment group and control group randomly.The former were treated with compound liver-benepitino remedy and antituberculosis drugs,and the later were treated with antituberculosis drugs and glucurolactone tablets.The course of the treatment was from 6 months to 8 months,and after completing the treatment,compare the clinical symptoms,physical signs and the function of liver between two groups.Results:In treatment group(192 cases),41 patients had the slight liver injure,but in control group,138 patients had the liver injure.The incidences were 21.4% in treatment group and 71.9% in control group respectively,and the difference was statistically significant(P0.05).In process of treatment,7(3.6%) patients' treatments were discontinued,and 21(10.9%)patients' treatments were discontinued,the difference between two groups was statistically significant(P0.05).Conclusions:Compound liver-benepitino remedy can prevent the liver injure caused by antituberculosis drugs,there are less side effects,and the side effects also were slight,so it have some clinical value.