Discovery of novel heterocyclic factor VIIa inhibitors.
Bioorganic & Medicinal Chemistry Letters（2006）
Abstract
The structure activity relationships and binding mode of novel heterocyclic Factor VIIa inhibitors will be described. In these inhibitors, a highly basic 5-amidinoindole moiety has been successfully replaced with a less basic 5-aminopyrrolo[3,2-b]pyridine scaffold.
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Key words
Factor VIIa,Inhibitor,fVIIa,Heterocyclic,5-aminopyrrolo[3,2-b]pyridine,Factor VIIa crystal structure,Anticoagulant
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