Studies on Chemical Constituents from Salix Babylonica L. and Their Stimulating Lipolysis Activity

To isolate flavonoids components from Salix Babylonica L. and study their effects on stimulating fat catabolism,flavonoids were isolated by Microwave Heating Extraction (MHE) and silica,Sephadex LH-20 column chromatography. The effects on NE-induced lipolysis and inhibiting intestine absorption for fatty acid were assessed by measuring the quantities of fatty acid. Three compounds were obtained from Salix Babylonica L.and identified as luteolin-7-O-β-D-glucopyranoside (Ⅰ),luteolin (Ⅱ) and chrysoeriol(Ⅲ). Compound Ⅲ was isolated from this plant for the first time. Pharmacological researches indicated that the three compounds can accelerate NE-induced lipolysis and inhibit the intestinal absorbtion for fatty acid. Among them Compound Ⅰ shows the strongest activities. Flavonoids from Salix babylonica L.could promote NE-induced lipolysis and be involved in the further exploitation of natural anti-obesity drugs.