Identification of 3',4',5'-trimethoxychalcone analogues as potent inhibitors of Helicobacter pylori-induced inflammation in human gastric epithelial cells.
Bioorganic & Medicinal Chemistry Letters（2010）
Abstract
Among 23 3′,4′,5′-trimethoxychalcone analogues tested, some of the chalcones displayed potent antibacterial activity against Helicobacter pylori, in addition, 1, 7, and 13 showed the bactericide activity against the reference as well as multidrug-resistant strains. Additionally, 1, 7, and 13 potentially inhibited the H. pylori-induced inflammation in human gastric epithelial cells.
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Key words
3′,4′,5′-Trimethoxychalcone analogues,Helicobacter pylori infection,Human gastric epithelial cells,Nuclear factor kappa B,Interleukin-8
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