Treatment of congenital Iong QT syndrome with permanent cardiac pacing

Objective:To evaluate the efficacy of permanent cardiac-pacing for treatment in pa- tients with congenital long QT syndrome.Methods:23 congenital long QT syndrome patients who occured torsade de points and failed to respond or intolerable to drugs were implanted VVI permanent cardiac pacemakers.The electrocardiogram and heart events were observed after the pacemaker im- plantation.Results:After pacemaker implantation,average QT interval was shortened from(638.0±55.7)ms to(471.3±48.9)ms(P=0.00025),QTc interval from(0.627±0.07)ms to(0.519±0.06)ms(P=0.00025)and the rate of recurrent cardiac events was significantly reduced from 0.353±0.46/yr to 0.111±(24/yr(P=0.039).During follow-up,90.91% patients were alive,77.5% patients had no cardiac events occurred and 2 patients died of TDP.Conclusions:Permanent VVI cardiac-pacing is one of the effective methods in the treatment of congenital LQTS patients by reduc- ing malignant arrhythmia.