Calcium Inhibition Of Dra Occurs By A Two-Step Process: Early Inhibition Of Membrane Resident Transporters Followed By Reduced Surface Expression

ligation.The ratio of CFTR/β-actin was significantly increased at the mid (0.65 ± 0.12, n= 5, P<0.05) and distal colon (0.74 ± 0.14, n=5, P<0.05) colon, compared to control rats (0.40 ± 0.07 in the mid colon, 0.43 ± 0.11 in the distal colon, n=5).CONCLUSION: It is suggested that fecal impaction due to partial anal ligation induces up-regulation of CFTR expression of the colonic mucosa.This alters function from a net absorptive to a net secretory state of the mid and distal colon.This could be an important compensatory mechanism to alleviate colonic distension due to fecal impaction.