Synthesis and antiviral activity of 4H-[1,2,5]oxadiazolo[3,4-d]pyrimidine-5,7-dione 1-oxide nucleosides

A series of 4H-[1,2,5]oxadiazolo[3,4-d]pyrimidine-5,7-dione 1-oxide nucleosides was designed, synthesized and evaluated against vesicular stomatitis virus (VSV) in Wish cell. The antiviral activities of all compounds were stronger than those of acyclovir, while their toxicities were similar to those of acyclovir.