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Angiotensin-(1–7) and vasopeptidase inhibition

C.M Ferrario,R.D Smith,C Yunis,K.B Brosnihan,C.E Grim, V Campese,M Ruddy,O Vesterqvist,W Liao

American Journal of Hypertension（2000）

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Abstract
A single molecule inhibiting neutral endopeptidase and angiotensin converting enzyme effectively controlled salt-sensitive hypertension by a mechanism related to inhibition of NEP 24.11 for which Ang-(1–7) is a substrate. These data are the first to show a role of Ang-(1–7) to the antihypertensive renal response of a novel vasopeptidase inhibitor in the treatment of essential hypertension.
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Key words
Ang-(1–7),omapatrilat,atrial natriuretic peptides,hypertension
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