Short-term efficacy of paclitxel plus cisplatin combined with adiotherapy on advanced cervix cancer

Objective:To observe the short-term efficacy and toxicity of paclitxel plus cisplatin combined with radiotherapy in treatment of advanced cervix cancer. Methods:Thirty-six patients with advanced cervix cancer(Ⅱb-Ⅲb)received concurrent chemoradiotherapy.The external irradiation dose of radiotherapy was 2Gy per time,5d/W,with a total dose of 50Gy;192Ir high-dose-rate afterloading unit was adopted for branchytherapy one week after external radiotherapy,at a dose of 7 Gy per time in A point for 6 times.Paclitxel(135mg/m2,d1) and cisplatin(25mg/m2,d1-d3) were given every 3-4 weeks for two cycles concurrently with radiotherapy.The short effectiveness and toxic reaction were observed in these patients. Results:Of the 36 cases,complete response was observed in 27 cases,partial response in 7 cases and two cases presented certain progress.The overall response rate was 94.4%.There was no statistical significance in differences of patients′ pathologic patterns and clinical stages(P0.05).The main toxicities were leucopenia and radiation rectal reaction. Conclusions:The short term efficacy of concurrent chemoradiotherapy with paclitxel and cisplatin is relatively good on patients with advanced cervical cancer,and the side effects are well tolerated.