Synthesis Of Nayf4 : Yb3+, Er3+@ Nagdf4@ Taox Multimodal Nanoprobe For Bioimaging Applications

Using solvothermal method, NaYF4:Yb3+, Er3+@ NaGdF4 was synthesized by deposition of a layer of NaGdF4 on the NaYF4: Yb3+, Er3+ upconverting nanoparticles (UCNPs) Then, NaYF4:Yb3+, Er3+@ NaGdF4 @ TaOx core@ shell@ shell nanoparticles were prepared through decorating the radiopaque but fluorescence-transparent TaOx onto the surface of NaYF4:Yb3+, Er3+ @ NaGdF4 by a facile reverse microemulsion strategy. The structure of the NaYF4: Yb3+, Er3+@ NaGdF4@ TaOx nanoparticle was characterized by transmission electron microscopy (TEM), powder X. ray diffraction (XRD), energy. dispersive X. ray analysis (EDS). The X. ray attenuation, magnetic and upconversion luminescent studies suggested that the as. prepared NaYF4:Yb3+, Er3+ @ NaGdF4 @ TaOx nanoparticle could be employed as multimodal nanoprobe for bioimaging applications. Furthermore, the feasibility of NaYF4: Yb3+, Er3+@ NaGdF4 @ TaOx for electronic computer X-ray transaction scan/magnetic resonance imaging (CT/MRI) in vivo was demonstrated. The brightness enhancement of MRI and CT signals in the tumor region were clearly observed at prolonged post. injection to 0. 5 h, indicating that the NaYF4:Yb3+, Er3+@ NaGdF4@ TaOx hold great potential for multimodal imaging in vivo.