胃癌和癌前病变组织中端粒酶、PCNA的表达及意义
Shandong Medical Journal(2008)
Abstract
目的探讨端粒酶、增殖细胞核抗原(PCNA)在胃癌发生发展中的作用。方法采用免疫组化SP法检测40例胃癌和18例癌前病变(其中慢性萎缩性胃炎伴肠化生10例,非典型增生8例)组织中端粒酶及PCNA。结果端粒酶在胃癌中的阳性表达率为80.00%,癌前病变为22.22%,两者相比,P<0.05;PCNA分别为72.50%、27.78%,两者相比,P<0.05。结论端粒酶和PCNA参与了胃癌的发生发展过程。检测端粒酶、PCNA对胃癌的早期诊断有一定的参考价值。
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Key words
telomerase,proliferating cell nuclear antigen,gastric carcinoma,precarcinoma lesion,gastric tumor
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