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Synthesis of (3,4-dimethoxyphenoxy)alkylamino acetamides as orexin-2 receptor antagonists

Andrew G. Cole,Ilana L. Stroke,Lan-Ying Qin,Zahid Hussain,Srilatha Simhadri,Marc-Raleigh Brescia,Frank S. Waksmunski,Barbara Strohl,John E. Tellew,John P. Williams,John Saunders,Kenneth C. Appell,Ian Henderson,Maria L. Webb

Bioorganic & Medicinal Chemistry Letters（2008）

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摘要
The synthesis and evaluation of (dimethoxyphenoxy)alkylamino acetamides as orexin-2 receptor antagonists are reported.
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关键词
Hypocretin,Orexin,GPCR,Combinatorial chemistry,ECLiPSTM
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