ADAM33基因多态性与吸烟人群COPD及其肺功能相关性
Journal of Clinical Pulmonary Medicine（2012）
Abstract
目的 探讨ADAM33基因多态性与吸烟人群COPD患者的相关性及其对COPD患者肺功能影响.方法 利用PCR-RFLP方法检测COPD患者和健康对照者ADAM33基因中的4个位点单核苷酸多态性,分析ADAM33基因与COPD相关性及其对COPD肺功能影响.结果 T2G(P ＜0.001),T1G(P ＜0.001),S2C(P=0.03)等位基因的频率COPD组明显高于对照组；T1GG(P =0.0189)、T2GG(P=0.0026)基因型较野生型基因FEV1％预计值明显降低；T1GG(P ＜0.001)、T2GG(P ＜0.001)基因型TLCO％预计值较野生型明显下降.结论 ADAM33基因多态性与吸烟人群COPD有关,并对COPD患者肺功能产生了影响.
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Key words
Single nucleotide polymorphism(SNPs),chronic obstructive pulmonary diseases(COPD),pulmonary function,A disintegrin and Metallopro-teinase domain33(ADAM33)
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