Relationship between Serum Leptin Level,Obesity and Sexual Development in Obese Boys

Objective To investigate the relationship between serum leptin level,obesity and sexual development in obese boys. Methods Thirty-four boys aged 9～14 years who were up to the standard of simple obesity were collected as obesity group,32 healthy boys were collected as control group.All subjects were computed for BMI.Their serum leptin level were measured with radioimmunoassay,and estradiol (E_2) and testosterone (T) were determined by the method of chemiluminescence,and the volume of testes were measured by vernier caliper to measure.SPSS 16.0 software was used to deal the data.The t test was used to compare the differences between 2 groups.Linear correlation analysis was used to analyze the relationship between leptin,BMI,estradiol and testosterone.Results The levels of serum leptin,estradiol and BMI of obese boys were much higher than control group,and had the significant differences with control group(P0.01).The levels of serum testosterone and volume of testes of obese boys were lower than that of control group,and the differences from the control group were statistically significant(P0.01).The levels of serum leptin of obese boys had the positive correlatiou with BMI(r=0.69,P0.01), had the positive correlation with E_2 (r=0.381,P0.05),had the negative correlation with T(r=-0.347,P0.05).Conclusion Obese boys has leptin-resistant,and has tendency for dysplasia of sexual development.