Effect of schisandrin on expression of both SYP and α-syn in brain tissue of the APP/PS1 double transgenic dementia mice

Aim To observe the effect of schisandrin on the APP/PS1 double transgenic dementia mice brain tissue and analyze the mechanism of it.Methods APP/PS1 double transgenic mice were selected as the dementia mice model and were intragastically administered with schisandrin(10 mg/kg·d).4 weeks later,the mice wre given a behavior test and then they were to collect their brain tissues for making the paraffin sections.Pathological changes of the mice brain tissue were examined using HE staining and nissl staining methods.The expression levels of synaptophysin(SYP) and α-synuclein(α-syn) in brain tissue were detected using immunohistochemical method.Results Schisandrin promoted the pathological changes of brain tissue in APP/PS1 double transgenic dementia mice,enhanced the expression of SYP,and reduced the expression of α-syn.Conclusions Schisandrin plays a role in preventing Alzheimer's Disease(AD) by alleviating neurons degeneration and demyelination and improving the function of synapses in brain tissue.