抑郁症患者血清CRP、CER、Hcy和Anti-CCP抗体的浓度变化
Practical Preventive Medicine(2012)
Abstract
目的探讨抑郁症患者血清C-反应蛋白(C-reactive protein,CRP)、铜蓝蛋白(copper-protein,CER)、同型半胱氨酸(Homocysteinc,Hcy)及抗环瓜氨酸肽抗体(anti-CCP)与抑郁症的关系。方法收集本院确诊的抑郁症患者55例,健康体检者30例,采用速率散射比浊法测血清CRP和CER,酶法测血清Hcy,酶联免疫吸附法测血清anti-CCP抗体,比较抑郁患者和正常对照人群的组间差异。结果与对照组比较,抑郁患者血清CRP水平无显著性变化(P>0.05),CER水平显著降低(P<0.05),Hcy和Anti-CCP水平均显著升高(P<0.05)。结论抑郁患者存在免疫炎症和自身免疫反应,CER、Hcy和anti-CCP均可能参与了抑郁症的病理进程。
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Key words
Anti-cyclic citrullinated peptide antibody,Depression,Homocysteine,Copper-protein,C-reactive protein
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