Split-split. A multiple synthesiser approach to efficient automated parallel synthesis

A multiple synthesiser approach to high efficiency, high throughput synthesis is described. It involves eliminating duplication in multi-step synthesis by establishing a cascade of matched synthesisers in which each machine performs a single step and provides feedstocks for the next instrument. The utility of this approach is illustrated by the efficient construction of a large array by a 4 step solution synthesis. (C) 1999 Elsevier Science Ltd. All rights reserved.