Molecular analysis of VHI+ B lymphocytes in hepatitis C patients

L. Galli-Stampino,A. Pasqualini,G. Pozzato, F. Bonino,F. Filipponi,M. Mosca,F. Masciopinto,S. Abrignani,Y. Uematsu

Digestive and Liver Disease（2003）

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摘要

Background and aims. Hepatitis C virus infection is often associated with lymphoproliferative disorders such as essential mixed cryoglobulinemia and B-cell non-Hodgkin lymphoma, which show preferential expression of VHI family products. By analyzing immunoglobulin heavy chain usage, we addressed the question of whether or not clonal B-cell expansion occurrs in patients free of essential mixed cryoglobulinemia or non-Hodgkin lymphoma.

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CDR3,EMC,HCV,IgH,IHL,LNL,NHL,NK,PBL,RF,TCR

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