Recent Advances in Psychoneuroimmunology: Inflammation in Psychiatric Disorders
Translational Neuroscience(2011)
摘要
Psychiatric disorders are common and complex and their precise biological underpinnings remain elusive. Multiple epidemiological, molecular, genetic and gene expression studies suggest that immune system dysfunction may contribute to the risk for developing psychiatric disorders including schizophrenia, bipolar disorder, and major depressive disorder. However, the precise mechanisms by which inflammation-related events confer such risk are unclear. In this review, we examine the peripheral and central evidence for inflammation in psychiatric disorders and the potential molecular mechanisms implicated including inhibition of neurogenesis, apoptosis, the HPA-axis, the role of brain-derived neurotrophic factor and the interplay between the glutamatergic, dopaminergic and serotonergic neurotransmitter systems.
更多查看译文
关键词
Inflammation,Cytokines,Etiology,Psychiatric disorders,Neurotransmitter imbalance,Maternal infections,Apoptosis,Brain Derived Neurotrophic Factor,Hypothalamic Pituitary Adrenal Axis,Glutamate,Dopamine,Serotonin,Quinolinic acid,Kynurenic acid
AI 理解论文
溯源树
样例
![](https://originalfileserver.aminer.cn/sys/aminer/pubs/mrt_preview.jpeg)
生成溯源树,研究论文发展脉络
Chat Paper
正在生成论文摘要