A stereoselective and scalable synthesis of a conformationally constrained S1P1 agonist
Tetrahedron Letters(2009)
摘要
A scalable and enantioselective synthesis of a potent S1P1 agonist containing two stereogenic centers on a cyclopentane ring is described. Control of the absolute chirality of an amino alcohol precursor, generated via a robust phase-transfer catalyzed alkylation protocol, allows for substrate directed hydrogenation to install the second stereogenic center providing access to gram-quantities of compound 2.
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关键词
agonist,scalable synthesis,stereoselective
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