Ad-HGF转染对HepG2细胞的生长抑制作用
Medical Journal of National Defending Forces in Northwest China（2008）
Abstract
目的:探讨Ad-HGF转染对HepG2生长抑制作用的影响.方法:用Ad-HGF转染HepG2细胞,检测HGF蛋白表达及对细胞凋亡的影响;并用裸鼠致瘤试验体内观察Ad-HGF对HepG2细胞致癌的影响.结果:转染后24 h HGF即有表达,48 h达高峰.并观察到Ad-HGF可促进HepG2凋亡,体内Ad-HGF可抑制HepG2细胞生长成瘤.结论:Ad-HGF在体外可抑制HepG2细胞增殖、促进其凋亡,体内抑制其致癌作用.
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Key words
Hepatocyte growth factor,Adenoviruses,Hepatocellular carcinoma
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