Inhibition of the c-Abl–TAp63 pathway protects mouse oocytes from chemotherapy-induced death

Chemotherapy often leads to premature death of oocytes, and thus infertility, in young individuals with cancer. Here, Stefania Gonfloni and her colleagues show that chemotherapy-induced activation of the kinase c-Abl is responsible for this oocyte failure and that, in vivo , the c-Abl inhibitor imatinib prevents this effect ( pages 1124–1125 ).