Deranged Energy-Metabolism In The Brain Of Newborn-Infants With Increased Cerebral Echodensities

Increased cerebral echodensities detected by ultrasound scanning of the brain in newborn infants often resolve, but sometimes progress to cystic periventricular leukoencephalopathy or other loss of brain tissue. The purpose of this investigation was to explore whether increased echodensities were associated with evidence of deranged cerebral energy metabolism as determined by phosphorus nuclear magnetic resonance spectroscopy (NMRS), and whether measurement of the energy status of cerebral tissue identified those infants who died or subsequently developed cysts or microcephaly.