HEMOADSORPTION OF HIGH-MOBILITY GROUP BOX 1 IN SWINE ACUTE LIVER FAILURE MODEL

72% in this cluster.In contrast, 124 (39%) of the patients with indeterminate etiology were classified into cluster-1 and 64 (20%) into cluster-3.Viral infection was the most prevalent etiology in both clusters (53% and 64%, respectively, in cluster-1 and cluster-3), but the causative virus differed between these clusters; transient infections of HAV and HBV were dominant in cluster-1, while HBV carriers showing acute hepatitis exacerbation prevailed in cluster-3.Discussion and Conclusion: ALF patients with indeterminate etiology were classified into three clusters.Considering the characters of patients belonging to each cluster, possible etiology of these patients was transient unknown virus infection in cluster-1, autoimmune hepatitis or drug-induced liver injury in cluster-2, and HBV occult infection in cluster-3.These possibilities should be further investigated.