Imidazolinones As Nonpeptide Angiotensin-Ii Receptor Antagonists

A series of biphenyl imidazolinones were synthesized as nonpeptide angiotensin II receptor antagonists. While those compounds with a tetrazole functionality were found to be AT(1) selective, those with a sulfonamide moiety showed affinities for both the AT(1) and the AT(2) sites. Representative compounds were very active in lowering blood pressure in conscious renal hypertensive rats following intravenous administration.