CDDO-Im is a stimulator of megakaryocytic differentiation.
Leukemia Research(2011)
Abstract
Although the triterpene CDDO and its potent derivatives, CDDO-Im and CDDO-Me, are now in phase I/II studies in the treatment of some pathological conditions, their effects on normal hematopoiesis are not known. In the present study we provide evidence that CDDO-Im exerts in vitro a potent inhibitory effect on erythroid cell proliferation and survival and a stimulatory action on megakaryocytic differentiation.
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Key words
Hematopoiesis,Megakaryocytes,Tripernes
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