Utilization Of Maltodextrin Based Enantio Selective, Potentiometric Membrane Electrodes For The Enantio Selective Assay Of S-Perindopril

Enantioselective, potentiometric membrane electrodes (EPMEs) based on carbon paste impregnated with different maltodextrins {dextrose equivalent (DE) 4.0-7.0 (I), 13.0-17.0 (II) and 16.5-19.5 (III)} as chiral selectors for the assay of S-perindopril is described. The proposed electrodes could be reliably employed in the assay of S-perindopril raw material and from its pharmaceutical formulation, Coversyl(R) tablets. The electrode based on maltodextrin (1) showed the best enantioselectivity and time-stability. The surfaces of the electrodes are easily renewable by simply polishing on an alumina paper. (C) 2003 Elsevier B.V. All rights reserved.