经皮瘤内注射联合肝动脉灌注热碘油治疗兔肝VX2瘤
Practical Journal of Medicine & Pharmacy(2013)
Abstract
目的 评价经皮穿刺瘤内注射联合肝动脉灌注60℃热碘油治疗兔VX2瘤的抑瘤效果.方法 将VX2瘤细胞接种于24只新西兰白兔左肝内,随机分为3组,经皮穿刺瘤内注射联合肝动脉灌注60℃热碘油3ml为联合组,经肝动脉灌注常温25℃碘油3ml为常温组,经肝动脉灌注化疗药物为对照组.术后10d计算瘤体坏死率,观察荷瘤兔的存活期及血清AST水平.结果 联合组肿瘤的生长率(0.85±0.31)%与对照组(3.16±0.65)%和常温组(1.52±0.36)%相比有显著性差异(P<0.05).联合组的存活期(48.3±3.0)d与常温组(39.2±2.5)d和对照组(31.5±3.5)d相比有显著性差异(P<0.05);术后10d血清AST,联合组与常温组及对照组相比无显著性差异(P>0.05).结论 经皮穿刺瘤内注射联合肝动脉灌注60℃热碘油治疗兔VX2瘤较单纯肝动脉栓塞或化疗更有效,能降低肿瘤生长率,延长存活时间.
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Key words
Intratumoral injection,Embolism,Rabbits,Heated lipiodol,VX2 tumor
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