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血脑脊液屏障相关转运蛋白与难治性癫(癎)

Journal of Applied Clinical Pediatrics(2012)

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Abstract
癫癎是神经科的常见病,多数患者预后良好.但仍有20%~ 30%的患者经正规抗癫癎药物规范治疗2a后不能有效控制成为难治性癫癎.血脑脊液屏障某些转运蛋白可能参与难治性癫癎耐药的机制,如P-糖蛋白、乳腺癌耐药蛋白、多药耐药相关蛋白等,且这些转运蛋白抑制剂如维拉帕米、丙磺舒等可能对难治性癫癎的治疗有帮助.现就这些转运蛋白与难治性癫癎耐药的关系做一综述.
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Key words
refractory epilepsy,blood-brain barrier,multi-drug resistance-associated protein,breast cancer resistance protein,P-glycoprotein
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