Unraveling the human interactome: lessons from the yeast

One of greatest promises of the post-genomic era is the use of genomic and proteomic information to discover how a cell works as a complex molecular machine. Mere cataloging of genes is insufficient for this purpose because the cellular architecture and functionality is largely decided by proteins and protein complexes. Elucidation of protein–protein interactions and networks is a challenging task that will require an integrated approach that combines different types of experiments in addition to bioinformatics analyses.