Synthesis and topoisomerase inhibitory activities of novel aza-analogues of flavones
European Journal of Medicinal Chemistry(1999)
Abstract
Aseries of aza-flavones (3-hydroxy-2-phenyl-4-quinolones) were designed and synthesized as inhibitors of bacterial DNA-gyrase and mammalian topoisomerase II. Structure activity relationships of the compounds against each of the enzymes are discussed.
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Key words
aza-flavones,3-hydroxy-2-phenyl-4-quinolones,DNA-gyrase,topoisomerase II
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