桑叶多糖对糖尿病大鼠Resistin蛋白表达的影响

Information on Traditional Chinese Medicine(2012)

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Abstract
目的:探讨桑叶多糖(Mulberry leaves polysaccharides,MLP)对2型糖尿(T2DM)病大鼠脂肪组织抵抗素(Resistin)蛋白表达的影响。方法:将Wistar大鼠随机分为空白对照组、模型组、MLP高、中、低剂量治疗组。用药12W后,采用SDS-PAGE检测Resistin蛋白质表达水平。结果:MLP高、中剂量治疗组Resistin蛋白表达低于模型组水平(P<0.01)。结论:MLP可通过下调2-DM大鼠Resistin蛋白表达,从而实现其降低IR的作用。
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Key words
T2DM,IR,Resistin,MLP
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