Anti-leukemia Activity of 7-hydroxy-2-substituted-methyl-5 H -oxazolo[3,2- a] pyrimidin-5-one Derivatives
JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY（2008）
Abstract
The synthesis of new 7-hydroxy-2-substituted-methyl-5 H -oxazolo[3,2- a ]pyrimidin-5-ones derivatives, designed as structural bicyclic analogues of the iron chelator deferiprone, is described. They were tested for their ability to inhibit proliferation in human Bcr-Abl(+) leukemia cells.
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Key words
anti-leukemia,iron chelator,oxazolo[3,2-a]pyrimidin-5-one
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