胰蛋白酶酶切EPO之多肽片段抑制EPO促CFU-E形成的研究

Xue-wen HUANG,Su-zhi LI,Xin-bin MU,Yu-qi GAO,You CHEN,Ren-ling LONG,Wen-chao HUANG,Xun LI,Ze-ping SUN,Yong HONG,Quan-gui SHI,Jun QUO,Jian-bao ZHENG,Li PAN,Gui-qiang HE,Xue-wen DONG

Medical Journal of National Defending Forces in Southwest China（2007）

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Abstract

目的:观察胰蛋白酶酶切EPO之多肽片段能否抑制EPO促红系形成.方法:对大鼠骨髓进行红系定向体外培养,加入胰蛋白酶酶切EPO之多肽片段干预,观察红系集落形成单位(CFU - E)之数量,判定胰蛋白酶酶切EPO之多肽片段对红系增殖活性的影响.结果:胰蛋白酶酶切EPO之多肽片段加入干预培养后,CFU - E数量明显减少(P＜0.01).结论: 胰蛋白酶酶切EPO之多肽产物体外能对抗EPO,抑制红系增殖. 其可作为治疗高原红细胞增多症的可能药物进一步研究.

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Key words

erythropoietin,colony-forming unit-erythroid,marrow

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