Synthesis of hexahydro[2]benzopyrano[3,4-c]pyrroles as serotonin 5-HT2C receptor agonists via intramolecular hetero Diels–Alder reactions

Takao Kiyoi,Mark Reid,Stuart Francis,Keneth Davies,Steven Laats,Duncan McArthur,Anna-Marie Easson,Yasuko Kiyoi,Gary Tarver,Wilson Caulfield,Kirsty Gibson,Grant Wishart,Angus J. Morrison,Julia M. Adam,Peter Ray

Tetrahedron Letters（2011）

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摘要

[2]Benzopyrano[3,4-c]pyrroles were synthesized via an intramolecular hetero Diels–Alder reaction. The reaction was applicable to a wide range of substrates and the products could be easily converted into serotonin 5-HT2C receptor agonists.

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关键词

Intramolecular hetero Diels–Alder reaction,[2]Benzopyrano[3,4-c]pyrroles,Serotonin 5-HT2C receptor agonists,Microwave-assisted synthesis

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