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3-Acyl-2,6-diaminopyridines as cyclin-dependent kinase inhibitors: synthesis and biological evaluation.

Ronghui Lin,Yanhua Lu,Steven K Wetter,Peter J Connolly,Ignatius J Turchi,William V Murray,Stuart L Emanuel,Robert H Gruninger,Angel R Fuentes-Pesquera,Mary Adams,Niranjan Pandey,Sandra Moreno-Mazza,Steven A Middleton,Linda K Jolliffe

Bioorganic & Medicinal Chemistry Letters（2005）

Cited 30|Views15
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Abstract
A novel series of 2,6-diamino-3-acylpyridines were designed and synthesized as cyclin-dependent kinase (CDK) inhibitors. The representative compounds 2r and 11 showed potent CDK1 and CDK2 inhibitory activities and inhibited cellular proliferation in HeLa, HCT116, and A375 tumor cells.
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Key words
Synthesis,Cyclin-dependent kinase inhibitor,CDK inhibitor,Cell proliferation inhibitor
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