3-Acyl-2,6-diaminopyridines as cyclin-dependent kinase inhibitors: synthesis and biological evaluation.
Bioorganic & Medicinal Chemistry Letters(2005)
Abstract
A novel series of 2,6-diamino-3-acylpyridines were designed and synthesized as cyclin-dependent kinase (CDK) inhibitors. The representative compounds 2r and 11 showed potent CDK1 and CDK2 inhibitory activities and inhibited cellular proliferation in HeLa, HCT116, and A375 tumor cells.
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Key words
Synthesis,Cyclin-dependent kinase inhibitor,CDK inhibitor,Cell proliferation inhibitor
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