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CD26/DP IV in T cell activation and autoimmunity.

Vera Preller,Annegret Gerber,Mauro Togni,Sabine Wrenger,Burkhart Schraven,Christoph Röcken,Didier Marguet,Siegfried Ansorge,Stefan Brocke,Dirk Reinhold

DIPEPTIDYL AMINOPEPTIDASES: BASIC SCIENCE AND CLINICAL APPLICATIONS（2006）

Cited 11|Views34
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Abstract
In summary, the present study demonstrates a critical role for CD26/DP IV in balancing Th1 immune responses. We observed a deregulation of the autoimmune process in EAE in vitro, the prototypic model of an immune-mediated CNS disorder. Our results support the notion of a critical regulatory role for the CD26/DP IV molecule within the immune system.
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Key words
Multiple Sclerosis, Experimental Autoimmune Encephalomyelitis, Myelin Basic Protein, Optic Neuritis, Dipeptidyl Peptidase
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