An evolutionarily conserved function of the Drosophila insulin receptor and insulin-like peptides in growth control.
Current Biology(2001)
Abstract
Background: Size regulation is fundamental in developing multicellular organisms and occurs through the control of cell number and cell size. Studies in Drosophila have identified an evolutionarily conserved signaling pathway that regulates organismal size and that includes the Drosophila insulin receptor substrate homolog Chico, the lipid kinase PI(3)K (Dp110), DAkt1/dPKB, and dS6K.
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Key words
insulin receptor,insulin receptor substrate,signaling pathway,kinase domain,biology
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