P11-13. Antigen presentation and immune priming of CCR5-ECL1 receptor in Peyer's patches B cells

Retrovirology(2009)

Cited 17|Views7
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Abstract
Background HIV protective downregulating CCR5-ECL1 IgA have been found in mucosal fluids from uninfected sexual partners of HIV-positive individuals and in a subset of HIV-seropositve HIV-controlling subjects. This finding concurred to the hypothesis that lack of expression of CCR5 might play a role in HIV protection. We induced and reproduced this immune status in animal models such as mouse and characterized the immune responses in Peyer's patches.
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Key words
Cell Tolerance,Immune Priming,Mucosal Site,Specific Antibody Response,Antigenic System
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