Asymmetric synthesis and absolute stereochemistry of 4,4-bis-(trifluoromethyl)imidazoline based ACAT inhibitors
TETRAHEDRON（1997）
Abstract
An asymmetric synthesis of 1, a potent orally active ACAT inhibitor, is reported. The absolute configuration of 1 has been determined by exciton CD spectra and X-ray crystal structure analysis. (C) 1997 The DuPont Merck Pharmaceutical Company.
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Key words
imidazoline,asymmetric synthesis,ACAT inhibitor,stereoselectivity,steroidal mimic
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