A Mammalian H+ Channel Generated Through Alternative Splicing Of The Nadph Oxidase Homolog Noh-1
SCIENCE(2000)
摘要
Voltage-gated proton (H+) channels are found in many human and animal tissues and play an important role in cellular defense against acidic stress. However, a molecular identification of these unique ion conductances has so far not been achieved. A 191-amino acid protein is described that, upon heterologous expression, has properties indistinguishable from those of native H+ channels. This protein is generated through alternative splicing of messenger RNA derived from the gene NOH-1 (NADPH oxidase homolog 1, where NADPH is the reduced form of nicotinamide adenine dinucleotide phosphate).
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关键词
amino acid,alternative splicing,heterologous expression,messenger rna
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